BENADRYL vs CHILDREN'S ASTEPRO ALLERGY

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	BENADRYL	CHILDREN'S ASTEPRO ALLERGY
Rating	New	New
Pharmacy pays	$0.04 /mL	$0.58 /mL
Type	RX	OTC
Active ingredient	DIPHENHYDRAMINE HYDROCHLORIDE	AZELASTINE HYDROCHLORIDE
Manufacturer	Mcneil Cons	Bayer Hlthcare
Dosage forms	Tablet, Kit	Spray/Inhaler, metered
Drug class	Histamine-1 Receptor Antagonist	Histamine-1 Receptor Antagonist
Boxed warning	None	None
Treats	Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness	Allergic Conjunctivitis, Perennial Allergic Rhinitis, Vasomotor Rhinitis

benadryl children's astepro allergy

Rating

New

Pharmacy pays

$0.04 /mL

$0.58 /mL

Type

OTC

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE

AZELASTINE HYDROCHLORIDE

Manufacturer

Mcneil Cons

Bayer Hlthcare

Dosage forms

Tablet, Kit

Spray/Inhaler, metered

Drug class

Histamine-1 Receptor Antagonist

Boxed warning

None

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

Allergic Conjunctivitis, Perennial Allergic Rhinitis, Vasomotor Rhinitis

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Frequently asked questions

Which is cheaper, Benadryl or Children's Astepro Allergy?

Benadryl costs pharmacies less to acquire — about $0.04 vs $0.58 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Benadryl and Children's Astepro Allergy?

Benadryl contains Diphenhydramine Hydrochloride, while Children's Astepro Allergy contains Azelastine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.