BENADRYL vs CHILDREN'S ALLEGRA HIVES

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. BENADRYL and CHILDREN'S ALLEGRA HIVES are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BENADRYL	CHILDREN'S ALLEGRA HIVES
Rating	New	New
Pharmacy pays	$0.04 /mL	~$7.33 /30
Type	RX	RX
Active ingredient	DIPHENHYDRAMINE HYDROCHLORIDE	FEXOFENADINE HYDROCHLORIDE
Manufacturer	Mcneil Cons	Chattem Sanofi
Dosage forms	Tablet, Kit	Tablet, orally disintegrating
Drug class	Histamine-1 Receptor Antagonist	Histamine-1 Receptor Antagonist
Boxed warning	None	None
Half-life	—	about 14 hours (label: mean elimination half-life 14.4 hours)
Treats	Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness	Perennial Allergic Rhinitis, Urticaria

benadryl children's allegra hives

Rating

New

Pharmacy pays

$0.04 /mL

~$7.33 /30

Type

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE

FEXOFENADINE HYDROCHLORIDE

Manufacturer

Mcneil Cons

Chattem Sanofi

Dosage forms

Tablet, Kit

Tablet, orally disintegrating

Drug class

Histamine-1 Receptor Antagonist

Boxed warning

None

Half-life

—

about 14 hours (label: mean elimination half-life 14.4 hours)

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

Perennial Allergic Rhinitis, Urticaria

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Frequently asked questions

What is the difference between Benadryl and Children's Allegra Hives?

Benadryl contains Diphenhydramine Hydrochloride, while Children's Allegra Hives contains Fexofenadine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.