AZULFIDINE vs LIALDA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. AZULFIDINE and LIALDA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AZULFIDINE	LIALDA
Rating	New	New
Pharmacy pays	~$5.92 /30	~$26.72 /30
Type	RX	RX
Active ingredient	SULFASALAZINE	MESALAMINE
Manufacturer	Pharmacia and Upjohn	Takeda Pharms USA
Dosage forms	Tablet	Tablet, delayed release
Drug class	Aminosalicylate	Aminosalicylate
Boxed warning	None	None
Half-life	—	about 7 to 9 hours (apparent terminal half-life)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Ulcerative Colitis	Ulcerative Colitis, Proctitis, Sigmoid Diseases

azulfidine lialda

Rating

New

Pharmacy pays

~$5.92 /30

~$26.72 /30

Type

Active ingredient

SULFASALAZINE

MESALAMINE

Manufacturer

Pharmacia and Upjohn

Takeda Pharms USA

Dosage forms

Tablet

Tablet, delayed release

Drug class

Aminosalicylate

Boxed warning

None

Half-life

—

about 7 to 9 hours (apparent terminal half-life)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Ulcerative Colitis

Ulcerative Colitis, Proctitis, Sigmoid Diseases

Frequently asked questions

Which is cheaper, Azulfidine or Lialda?

Azulfidine costs pharmacies less to acquire — about $5.92 vs $26.72 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Azulfidine and Lialda?

Azulfidine contains Sulfasalazine, while Lialda contains Mesalamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.