AZULFIDINE EN-TABS vs MESALAMINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. AZULFIDINE EN-TABS and MESALAMINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AZULFIDINE EN-TABS	MESALAMINE
Rating	64/100	New
Pharmacy pays	~$5.92 /30	~$26.72 /30
Type	RX	RX
Active ingredient	SULFASALAZINE	MESALAMINE
Manufacturer	Pfizer	Actavis Mid Atlantic
Dosage forms	Tablet, delayed release	Capsule, delayed release, Capsule, extended release, Enema, Suppository, Suspension, Tablet, delayed release, Kit
Drug class	Aminosalicylate	Aminosalicylate
Boxed warning	None	None
Half-life	—	about 7 to 9 hours (apparent terminal half-life)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Ulcerative Colitis	Ulcerative Colitis, Proctitis, Sigmoid Diseases

azulfidine en-tabs mesalamine

Rating

64/100

New

Pharmacy pays

~$5.92 /30

~$26.72 /30

Type

Active ingredient

SULFASALAZINE

MESALAMINE

Manufacturer

Pfizer

Actavis Mid Atlantic

Dosage forms

Tablet, delayed release

Capsule, delayed release, Capsule, extended release, Enema, Suppository, Suspension, Tablet, delayed release, Kit

Drug class

Aminosalicylate

Boxed warning

None

Half-life

—

about 7 to 9 hours (apparent terminal half-life)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Ulcerative Colitis

Ulcerative Colitis, Proctitis, Sigmoid Diseases

Frequently asked questions

Which is cheaper, Azulfidine En-Tabs or Mesalamine?

Azulfidine En-Tabs costs pharmacies less to acquire — about $5.92 vs $26.72 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Azulfidine En-Tabs and Mesalamine?

Azulfidine En-Tabs contains Sulfasalazine, while Mesalamine contains Mesalamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.