AYVAKIT vs MEKINIST

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. AYVAKIT and MEKINIST are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AYVAKIT	MEKINIST
Rating	New	70/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	AVAPRITINIB	TRAMETINIB DIMETHYL SULFOXIDE
Manufacturer	Blueprint Medicines	Novartis
Dosage forms	Tablet	Powder, Tablet
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	None
Treats	Gastrointestinal Stromal Tumors	Non-Small-Cell Lung Carcinoma, Melanoma

ayvakit mekinist

Rating

New

70/100

Pharmacy pays

—

Type

Active ingredient

AVAPRITINIB

TRAMETINIB DIMETHYL SULFOXIDE

Manufacturer

Blueprint Medicines

Novartis

Dosage forms

Tablet

Powder, Tablet

Drug class

Kinase Inhibitor

Boxed warning

None

Treats

Gastrointestinal Stromal Tumors

Non-Small-Cell Lung Carcinoma, Melanoma

Frequently asked questions

What is the difference between Ayvakit and Mekinist?

Ayvakit contains Avapritinib, while Mekinist contains Trametinib Dimethyl Sulfoxide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.