AYVAKIT vs ICLUSIG

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. AYVAKIT and ICLUSIG are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AYVAKIT	ICLUSIG
Rating	New	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	AVAPRITINIB	PONATINIB HYDROCHLORIDE
Manufacturer	Blueprint Medicines	Takeda Pharms USA
Dosage forms	Tablet	Tablet
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	Boxed warning
Treats	Gastrointestinal Stromal Tumors	Myeloid Leukemia

ayvakit iclusig

Rating

New

Pharmacy pays

—

Type

Active ingredient

AVAPRITINIB

PONATINIB HYDROCHLORIDE

Manufacturer

Blueprint Medicines

Takeda Pharms USA

Dosage forms

Tablet

Drug class

Kinase Inhibitor

Boxed warning

None

Boxed warning

Treats

Gastrointestinal Stromal Tumors

Myeloid Leukemia

Frequently asked questions

What is the difference between Ayvakit and Iclusig?

Ayvakit contains Avapritinib, while Iclusig contains Ponatinib Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.