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AYGESTIN vs MEGACE ES

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. AYGESTIN and MEGACE ES are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
New

Pharmacy pays

~$2.83 /30
~$7.14 /30

Type

RX
RX

Active ingredient

NORETHINDRONE ACETATE
MEGESTROL ACETATE

Dosage forms

Tablet
Suspension

Drug class

Progestin
Progestin

Boxed warning

None
None

Half-life

about 8 hours

Treats

Acne Vulgaris, Endometrial Hyperplasia, Endometriosis
Anorexia, Breast Neoplasms, Cachexia

Get aygestinhigher-rated option

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Frequently asked questions

Which is cheaper, Aygestin or Megace Es?

Aygestin costs pharmacies less to acquire — about $2.83 vs $7.14 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Aygestin and Megace Es?

Aygestin contains Norethindrone Acetate, while Megace Es contains Megestrol Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.