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AXID vs PEPCID PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. AXID and PEPCID PRESERVATIVE FREE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

~$24.82 /30
~$1.54 /30

Type

RX
RX

Active ingredient

NIZATIDINE
FAMOTIDINE

Dosage forms

Capsule, Solution
Injectable

Drug class

Histamine-2 Receptor Antagonist
Histamine-2 Receptor Antagonist

Boxed warning

None
None

Half-life

2.5 to 3.5 hours

Treats

Duodenal Ulcer, Dyspepsia, Peptic Esophagitis
Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

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Frequently asked questions

Which is cheaper, Axid or Pepcid Preservative Free?

Pepcid Preservative Free costs pharmacies less to acquire — about $1.54 vs $24.82 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Axid and Pepcid Preservative Free?

Axid contains Nizatidine, while Pepcid Preservative Free contains Famotidine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.