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AVITA vs DIFFERIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. AVITA and DIFFERIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
New

Pharmacy pays

$1.05 /g
$0.51 /g

Type

RX
RX

Active ingredient

TRETINOIN
ADAPALENE

Dosage forms

Topical
Topical

Drug class

Retinoid
Retinoid

Boxed warning

None
None

Treats

Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia
Acne Vulgaris

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Frequently asked questions

Which is cheaper, Avita or Differin?

Differin costs pharmacies less to acquire — about $0.51 vs $1.05 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Avita and Differin?

Avita contains Tretinoin, while Differin contains Adapalene — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.