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AVINZA vs DURAGESIC-50

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. AVINZA and DURAGESIC-50 are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

$2.61 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

MORPHINE SULFATE
FENTANYL

Dosage forms

Capsule, extended release
Film, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 2 hours

Treats

Dyspnea, Intractable Pain
Pain

Frequently asked questions

Which is cheaper, Avinza or Duragesic-50?

Avinza costs pharmacies less to acquire — about $2.61 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Avinza and Duragesic-50?

Avinza contains Morphine Sulfate, while Duragesic-50 contains Fentanyl — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.