AVENTYL vs ZONALON

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 14, 2026·How we rate

Possible drug interaction. AVENTYL and ZONALON are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AVENTYL	ZONALON
Rating	72/100	66/100
Pharmacy pays	$0.17 /mL	~$4.84 /30
Type	RX	RX
Active ingredient	NORTRIPTYLINE HYDROCHLORIDE	DOXEPIN HYDROCHLORIDE
Manufacturer	Ranbaxy	Mylan
Dosage forms	Solution	Topical
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Half-life	—	about 8 to 24 hours (average about 17 hours)
Treats	Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder	Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

aventyl zonalon

Rating

72/100

66/100

Pharmacy pays

$0.17 /mL

~$4.84 /30

Type

Active ingredient

NORTRIPTYLINE HYDROCHLORIDE

DOXEPIN HYDROCHLORIDE

Manufacturer

Ranbaxy

Mylan

Dosage forms

Solution

Topical

Drug class

Tricyclic Antidepressant

Boxed warning

None

Half-life

—

about 8 to 24 hours (average about 17 hours)

Treats

Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder

Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

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Frequently asked questions

Which is better-rated, Aventyl or Zonalon?

By our independent rating, Aventyl scores higher — 3.6 vs 3.3 out of 5 for Zonalon. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Aventyl and Zonalon?

Aventyl contains Nortriptyline Hydrochloride, while Zonalon contains Doxepin Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.