AVANDARYL vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. AVANDARYL and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AVANDARYL	MYSOLINE
Rating	New	74/100
Pharmacy pays	~$0.91 /30	~$2.89 /30
Type	RX	RX
Active ingredient	GLIMEPIRIDE AND ROSIGLITAZONE MALEATE	PRIMIDONE
Manufacturer	Sb Pharmco	Valeant Pharm Intl
Dosage forms	Tablet	Tablet
Drug class	—	Anti-Epileptic Agent
Boxed warning	None	None
Half-life	about 5 hours (label mean 5.3 hours in adults, ± 4.1 hours — variation between people is wide)	—
Treats	—	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

avandaryl mysoline

Rating

New

74/100

Pharmacy pays

~$0.91 /30

~$2.89 /30

Type

Active ingredient

GLIMEPIRIDE AND ROSIGLITAZONE MALEATE

PRIMIDONE

Manufacturer

Sb Pharmco

Valeant Pharm Intl

Dosage forms

Tablet

Drug class

—

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 5 hours (label mean 5.3 hours in adults, ± 4.1 hours — variation between people is wide)

—

Treats

—

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is cheaper, Avandaryl or Mysoline?

Avandaryl costs pharmacies less to acquire — about $0.91 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Avandaryl and Mysoline?

Avandaryl contains Glimepiride and Rosiglitazone Maleate, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.