AVANDARYL vs CUPRIMINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. AVANDARYL and CUPRIMINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AVANDARYL	CUPRIMINE
Rating	New	74/100
Pharmacy pays	~$0.91 /30	—
Type	RX	RX
Active ingredient	GLIMEPIRIDE AND ROSIGLITAZONE MALEATE	PENICILLAMINE
Manufacturer	Sb Pharmco	Valeant Pharm Intl
Dosage forms	Tablet	Capsule
Drug class	—	Antirheumatic Agent
Boxed warning	None	Boxed warning
Half-life	about 5 hours (label mean 5.3 hours in adults, ± 4.1 hours — variation between people is wide)	—
Treats	—	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

avandaryl cuprimine

Rating

New

74/100

Pharmacy pays

~$0.91 /30

—

Type

Active ingredient

GLIMEPIRIDE AND ROSIGLITAZONE MALEATE

PENICILLAMINE

Manufacturer

Sb Pharmco

Valeant Pharm Intl

Dosage forms

Tablet

Capsule

Drug class

—

Antirheumatic Agent

Boxed warning

None

Boxed warning

Half-life

about 5 hours (label mean 5.3 hours in adults, ± 4.1 hours — variation between people is wide)

—

Treats

—

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

Frequently asked questions

What is the difference between Avandaryl and Cuprimine?

Avandaryl contains Glimepiride and Rosiglitazone Maleate, while Cuprimine contains Penicillamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.