AVANDAMET vs CUPRIMINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 5, 2026·How we rate

Possible drug interaction. AVANDAMET and CUPRIMINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AVANDAMET	CUPRIMINE
Rating	New	74/100
Pharmacy pays	~$0.74 /30	—
Type	RX	RX
Active ingredient	METFORMIN HYDROCHLORIDE AND ROSIGLITAZONE MALEATE	PENICILLAMINE
Manufacturer	Sb Pharmco	Valeant Pharm Intl
Dosage forms	Tablet	Capsule
Drug class	—	Antirheumatic Agent
Boxed warning	None	Boxed warning
Half-life	about 6.2 hours (plasma elimination half-life in adults with normal kidney function)	—
Treats	—	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

avandamet cuprimine

Rating

New

74/100

Pharmacy pays

~$0.74 /30

—

Type

Active ingredient

METFORMIN HYDROCHLORIDE AND ROSIGLITAZONE MALEATE

PENICILLAMINE

Manufacturer

Sb Pharmco

Valeant Pharm Intl

Dosage forms

Tablet

Capsule

Drug class

—

Antirheumatic Agent

Boxed warning

None

Boxed warning

Half-life

about 6.2 hours (plasma elimination half-life in adults with normal kidney function)

—

Treats

—

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

Frequently asked questions

What is the difference between Avandamet and Cuprimine?

Avandamet contains Metformin Hydrochloride and Rosiglitazone Maleate, while Cuprimine contains Penicillamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.