AUVELITY vs RETIN-A

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. AUVELITY and RETIN-A are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AUVELITY	RETIN-A
Rating	New	74/100
Pharmacy pays	~$2.51 /30	$1.05 /g
Type	RX	RX
Active ingredient	BUPROPION HYDROCHLORIDE AND DEXTROMETHORPHAN HYDROBROMIDE	TRETINOIN
Manufacturer	Axsome	Valeant Pharm Intl
Dosage forms	Tablet, Multilayer, extended release, Kit	Topical
Drug class	—	Retinoid
Boxed warning	Boxed warning	None
Half-life	about 21 hours on average (±9 hours)	—
Treats	—	Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

auvelity retin-a

Rating

New

74/100

Pharmacy pays

~$2.51 /30

$1.05 /g

Type

Active ingredient

BUPROPION HYDROCHLORIDE AND DEXTROMETHORPHAN HYDROBROMIDE

TRETINOIN

Manufacturer

Axsome

Valeant Pharm Intl

Dosage forms

Tablet, Multilayer, extended release, Kit

Topical

Drug class

—

Retinoid

Boxed warning

None

Half-life

about 21 hours on average (±9 hours)

—

Treats

—

Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

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Frequently asked questions

What is the difference between Auvelity and Retin-A?

Auvelity contains Bupropion Hydrochloride and Dextromethorphan Hydrobromide, while Retin-A contains Tretinoin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.