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ASTELIN vs BENYLIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. ASTELIN and BENYLIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
New

Pharmacy pays

$0.58 /mL
$0.04 /mL

Type

RX
RX

Active ingredient

AZELASTINE HYDROCHLORIDE
DIPHENHYDRAMINE HYDROCHLORIDE

Manufacturer

Dosage forms

Spray/Inhaler, metered
Syrup, Solution

Drug class

Histamine-1 Receptor Antagonist
Histamine-1 Receptor Antagonist

Boxed warning

None
None

Treats

Allergic Conjunctivitis, Perennial Allergic Rhinitis, Vasomotor Rhinitis
Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

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Frequently asked questions

Which is cheaper, Astelin or Benylin?

Benylin costs pharmacies less to acquire — about $0.04 vs $0.58 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Astelin and Benylin?

Astelin contains Azelastine Hydrochloride, while Benylin contains Diphenhydramine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.