ASTAGRAF XL vs PROTOPIC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	ASTAGRAF XL	PROTOPIC
Rating	70/100	New
Pharmacy pays	$0.65 /g	$0.65 /g
Type	RX	RX
Active ingredient	TACROLIMUS	TACROLIMUS
Manufacturer	Astellas	Leo Pharma As
Dosage forms	Capsule, extended release	Topical
Drug class	Calcineurin Inhibitor Immunosuppressant	Calcineurin Inhibitor Immunosuppressant
Boxed warning	Boxed warning	None
Treats	Atopic Dermatitis, Graft Vs Host Disease	Atopic Dermatitis, Graft Vs Host Disease

astagraf xl protopic

Rating

70/100

New

Pharmacy pays

$0.65 /g

Type

Active ingredient

TACROLIMUS

Manufacturer

Astellas

Leo Pharma As

Dosage forms

Capsule, extended release

Topical

Drug class

Calcineurin Inhibitor Immunosuppressant

Boxed warning

None

Treats

Atopic Dermatitis, Graft Vs Host Disease

Frequently asked questions

Which is cheaper, Astagraf XL or Protopic?

Pharmacies pay about the same to acquire either one — roughly $0.65 per gm, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Astagraf XL and Protopic?

Both Astagraf XL and Protopic share the active ingredient Tacrolimus.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.