ASTAGRAF XL vs PROGRAF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	ASTAGRAF XL	PROGRAF
Rating	70/100	72/100
Pharmacy pays	$0.65 /g	$0.65 /g
Type	RX	RX
Active ingredient	TACROLIMUS	TACROLIMUS
Manufacturer	Astellas	Astellas
Dosage forms	Capsule, extended release	Capsule, Powder, Injectable
Drug class	Calcineurin Inhibitor Immunosuppressant	Calcineurin Inhibitor Immunosuppressant
Boxed warning	Boxed warning	Boxed warning
Treats	Atopic Dermatitis, Graft Vs Host Disease	Atopic Dermatitis, Graft Vs Host Disease

astagraf xl prograf

Rating

70/100

72/100

Pharmacy pays

$0.65 /g

Type

Active ingredient

TACROLIMUS

Manufacturer

Astellas

Dosage forms

Capsule, extended release

Capsule, Powder, Injectable

Drug class

Calcineurin Inhibitor Immunosuppressant

Boxed warning

Treats

Atopic Dermatitis, Graft Vs Host Disease

Frequently asked questions

Which is better-rated, Astagraf XL or Prograf?

By our independent rating, Prograf scores higher — 3.6 vs 3.5 out of 5 for Astagraf XL. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Astagraf XL or Prograf?

Pharmacies pay about the same to acquire either one — roughly $0.65 per gm, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Astagraf XL and Prograf?

Both Astagraf XL and Prograf share the active ingredient Tacrolimus.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.