ASTAGRAF XL vs LUPKYNIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. ASTAGRAF XL and LUPKYNIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ASTAGRAF XL	LUPKYNIS
Rating	70/100	New
Pharmacy pays	$0.65 /g	—
Type	RX	RX
Active ingredient	TACROLIMUS	VOCLOSPORIN
Manufacturer	Astellas	Aurinia
Dosage forms	Capsule, extended release	Capsule
Drug class	Calcineurin Inhibitor Immunosuppressant	Calcineurin Inhibitor Immunosuppressant
Boxed warning	Boxed warning	None
Treats	Atopic Dermatitis, Graft Vs Host Disease	Lupus Nephritis

astagraf xl lupkynis

Rating

70/100

New

Pharmacy pays

$0.65 /g

—

Type

Active ingredient

TACROLIMUS

VOCLOSPORIN

Manufacturer

Astellas

Aurinia

Dosage forms

Capsule, extended release

Capsule

Drug class

Calcineurin Inhibitor Immunosuppressant

Boxed warning

None

Treats

Atopic Dermatitis, Graft Vs Host Disease

Lupus Nephritis

Frequently asked questions

What is the difference between Astagraf XL and Lupkynis?

Astagraf XL contains Tacrolimus, while Lupkynis contains Voclosporin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.