ASTAGRAF XL vs GENGRAF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. ASTAGRAF XL and GENGRAF are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ASTAGRAF XL	GENGRAF
Rating	70/100	72/100
Pharmacy pays	$0.65 /g	~$52.85 /30
Type	RX	RX
Active ingredient	TACROLIMUS	CYCLOSPORINE
Manufacturer	Astellas	Abbvie
Dosage forms	Capsule, extended release	Capsule
Drug class	Calcineurin Inhibitor Immunosuppressant	Calcineurin Inhibitor Immunosuppressant
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 8.4 hours (range 5 to 18 hours)
Treats	Atopic Dermatitis, Graft Vs Host Disease	Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

astagraf xl gengraf

Rating

70/100

72/100

Pharmacy pays

$0.65 /g

~$52.85 /30

Type

Active ingredient

TACROLIMUS

CYCLOSPORINE

Manufacturer

Astellas

Abbvie

Dosage forms

Capsule, extended release

Capsule

Drug class

Calcineurin Inhibitor Immunosuppressant

Boxed warning

Half-life

—

about 8.4 hours (range 5 to 18 hours)

Treats

Atopic Dermatitis, Graft Vs Host Disease

Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

Frequently asked questions

Which is better-rated, Astagraf XL or Gengraf?

By our independent rating, Gengraf scores higher — 3.6 vs 3.5 out of 5 for Astagraf XL. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Astagraf XL and Gengraf?

Astagraf XL contains Tacrolimus, while Gengraf contains Cyclosporine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.