ASTAGRAF XL vs ENVARSUS XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	ASTAGRAF XL	ENVARSUS XR
Rating	70/100	New
Pharmacy pays	$0.65 /g	$0.65 /g
Type	RX	RX
Active ingredient	TACROLIMUS	TACROLIMUS
Manufacturer	Astellas	Veloxis Pharms Inc
Dosage forms	Capsule, extended release	Tablet, extended release
Drug class	Calcineurin Inhibitor Immunosuppressant	Calcineurin Inhibitor Immunosuppressant
Boxed warning	Boxed warning	Boxed warning
Treats	Atopic Dermatitis, Graft Vs Host Disease	Atopic Dermatitis, Graft Vs Host Disease

astagraf xl envarsus xr

Rating

70/100

New

Pharmacy pays

$0.65 /g

Type

Active ingredient

TACROLIMUS

Manufacturer

Astellas

Veloxis Pharms Inc

Dosage forms

Capsule, extended release

Tablet, extended release

Drug class

Calcineurin Inhibitor Immunosuppressant

Boxed warning

Treats

Atopic Dermatitis, Graft Vs Host Disease

Frequently asked questions

Which is cheaper, Astagraf XL or Envarsus XR?

Pharmacies pay about the same to acquire either one — roughly $0.65 per gm, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Astagraf XL and Envarsus XR?

Both Astagraf XL and Envarsus XR share the active ingredient Tacrolimus.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.