ASTAGRAF XL vs DUPIXENT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. ASTAGRAF XL and DUPIXENT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ASTAGRAF XL	DUPIXENT
Rating	70/100	70/100
Pharmacy pays	$0.65 /g	—
Type	RX	RX
Active ingredient	TACROLIMUS	DUPILUMAB
Manufacturer	Astellas	Regeneron Pharmaceuticals
Dosage forms	Capsule, extended release	Injectable
Drug class	Calcineurin Inhibitor Immunosuppressant	Interleukin-4 Receptor Alpha Antagonist
Boxed warning	Boxed warning	None
Treats	Atopic Dermatitis, Graft Vs Host Disease	Atopic Dermatitis

astagraf xl dupixent

Rating

70/100

Pharmacy pays

$0.65 /g

—

Type

Active ingredient

TACROLIMUS

DUPILUMAB

Manufacturer

Astellas

Regeneron Pharmaceuticals

Dosage forms

Capsule, extended release

Injectable

Drug class

Calcineurin Inhibitor Immunosuppressant

Interleukin-4 Receptor Alpha Antagonist

Boxed warning

None

Treats

Atopic Dermatitis, Graft Vs Host Disease

Atopic Dermatitis

Frequently asked questions

Which is better-rated, Astagraf XL or Dupixent?

Astagraf XL and Dupixent are tied at 3.5 out of 5 by our independent rating.

What is the difference between Astagraf XL and Dupixent?

Astagraf XL contains Tacrolimus, while Dupixent contains Dupilumab — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.