ASENAPINE MALEATE vs INVEGA SUSTENNA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. ASENAPINE MALEATE and INVEGA SUSTENNA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ASENAPINE MALEATE	INVEGA SUSTENNA
Rating	70/100	70/100
Pharmacy pays	~$73.98 /30	—
Type	RX	RX
Active ingredient	ASENAPINE MALEATE	PALIPERIDONE PALMITATE
Manufacturer	Breckenridge	Janssen Pharms
Dosage forms	Tablet	Injectable
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	about 24 hours (terminal/elimination half-life)	—
Treats	Bipolar Disorder, Schizophrenia	Bipolar Disorder, Depressive Disorder, Schizophrenia

asenapine maleate invega sustenna

Rating

70/100

Pharmacy pays

~$73.98 /30

—

Type

Active ingredient

ASENAPINE MALEATE

PALIPERIDONE PALMITATE

Manufacturer

Breckenridge

Janssen Pharms

Dosage forms

Tablet

Injectable

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

about 24 hours (terminal/elimination half-life)

—

Treats

Bipolar Disorder, Schizophrenia

Bipolar Disorder, Depressive Disorder, Schizophrenia

Frequently asked questions

Which is better-rated, Asenapine Maleate or Invega Sustenna?

Asenapine Maleate and Invega Sustenna are tied at 3.5 out of 5 by our independent rating.

What is the difference between Asenapine Maleate and Invega Sustenna?

Asenapine Maleate contains Asenapine Maleate, while Invega Sustenna contains Paliperidone Palmitate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.