ASENAPINE MALEATE vs CLOZAPINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. ASENAPINE MALEATE and CLOZAPINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ASENAPINE MALEATE	CLOZAPINE
Rating	70/100	70/100
Pharmacy pays	~$73.98 /30	~$30.62 /30
Type	RX	RX
Active ingredient	ASENAPINE MALEATE	CLOZAPINE
Manufacturer	Breckenridge	Par Pharm
Dosage forms	Tablet	Tablet, Tablet, orally disintegrating
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	None
Half-life	about 24 hours (terminal/elimination half-life)	about 12 hours at steady state (the label gives a mean elimination half-life of 12 hours, range 4 to 66 hours, after 100 mg twice daily); after a single 75 mg dose the mean is 8 hours (range 4 to 12 hours)
Treats	Bipolar Disorder, Schizophrenia	Bipolar Disorder, Psychotic Disorders, Schizophrenia

asenapine maleate clozapine

Rating

70/100

Pharmacy pays

~$73.98 /30

~$30.62 /30

Type

Active ingredient

ASENAPINE MALEATE

CLOZAPINE

Manufacturer

Breckenridge

Par Pharm

Dosage forms

Tablet

Tablet, Tablet, orally disintegrating

Drug class

Atypical Antipsychotic

Boxed warning

None

Half-life

about 24 hours (terminal/elimination half-life)

about 12 hours at steady state (the label gives a mean elimination half-life of 12 hours, range 4 to 66 hours, after 100 mg twice daily); after a single 75 mg dose the mean is 8 hours (range 4 to 12 hours)

Treats

Bipolar Disorder, Schizophrenia

Bipolar Disorder, Psychotic Disorders, Schizophrenia

Frequently asked questions

Which is better-rated, Asenapine Maleate or Clozapine?

Asenapine Maleate and Clozapine are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Asenapine Maleate or Clozapine?

Clozapine costs pharmacies less to acquire — about $30.62 vs $73.98 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Asenapine Maleate and Clozapine?

Asenapine Maleate contains Asenapine Maleate, while Clozapine contains Clozapine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.