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ASACOL HD vs AZULFIDINE EN-TABS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. ASACOL HD and AZULFIDINE EN-TABS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
64/100

Pharmacy pays

~$26.72 /30
~$5.92 /30

Type

RX
RX

Active ingredient

MESALAMINE
SULFASALAZINE

Manufacturer

Dosage forms

Tablet, delayed release
Tablet, delayed release

Drug class

Aminosalicylate
Aminosalicylate

Boxed warning

None
None

Half-life

about 7 to 9 hours (apparent terminal half-life)

Treats

Ulcerative Colitis, Proctitis, Sigmoid Diseases
Juvenile Arthritis, Rheumatoid Arthritis, Ulcerative Colitis

Frequently asked questions

Which is better-rated, Asacol Hd or Azulfidine En-Tabs?

By our independent rating, Asacol Hd scores higher — 3.6 vs 3.2 out of 5 for Azulfidine En-Tabs. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Asacol Hd or Azulfidine En-Tabs?

Azulfidine En-Tabs costs pharmacies less to acquire — about $5.92 vs $26.72 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Asacol Hd and Azulfidine En-Tabs?

Asacol Hd contains Mesalamine, while Azulfidine En-Tabs contains Sulfasalazine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.