ASACOL HD vs AZULFIDINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. ASACOL HD and AZULFIDINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ASACOL HD	AZULFIDINE
Rating	72/100	New
Pharmacy pays	~$26.72 /30	~$5.92 /30
Type	RX	RX
Active ingredient	MESALAMINE	SULFASALAZINE
Manufacturer	Abbvie	Pharmacia and Upjohn
Dosage forms	Tablet, delayed release	Tablet
Drug class	Aminosalicylate	Aminosalicylate
Boxed warning	None	None
Half-life	about 7 to 9 hours (apparent terminal half-life)	—
Treats	Ulcerative Colitis, Proctitis, Sigmoid Diseases	Juvenile Arthritis, Rheumatoid Arthritis, Ulcerative Colitis

asacol hd azulfidine

Rating

72/100

New

Pharmacy pays

~$26.72 /30

~$5.92 /30

Type

Active ingredient

MESALAMINE

SULFASALAZINE

Manufacturer

Abbvie

Pharmacia and Upjohn

Dosage forms

Tablet, delayed release

Tablet

Drug class

Aminosalicylate

Boxed warning

None

Half-life

about 7 to 9 hours (apparent terminal half-life)

—

Treats

Ulcerative Colitis, Proctitis, Sigmoid Diseases

Juvenile Arthritis, Rheumatoid Arthritis, Ulcerative Colitis

Frequently asked questions

Which is cheaper, Asacol Hd or Azulfidine?

Azulfidine costs pharmacies less to acquire — about $5.92 vs $26.72 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Asacol Hd and Azulfidine?

Asacol Hd contains Mesalamine, while Azulfidine contains Sulfasalazine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.