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AROMASIN vs LETROZOLE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. AROMASIN and LETROZOLE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

64/100
72/100

Pharmacy pays

~$18.36 /30
~$4.50 /30

Type

RX
RX

Active ingredient

EXEMESTANE
LETROZOLE

Manufacturer

Dosage forms

Tablet
Tablet

Drug class

Aromatase Inhibitor
Aromatase Inhibitor

Boxed warning

None
None

Half-life

about 2 days (terminal elimination half-life)

Treats

Breast Neoplasms
Breast Neoplasms

Frequently asked questions

Which is better-rated, Aromasin or Letrozole?

By our independent rating, Letrozole scores higher — 3.6 vs 3.2 out of 5 for Aromasin. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Aromasin or Letrozole?

Letrozole costs pharmacies less to acquire — about $4.50 vs $18.36 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Aromasin and Letrozole?

Aromasin contains Exemestane, while Letrozole contains Letrozole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.