ARAVA vs DEPEN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. ARAVA and DEPEN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ARAVA	DEPEN
Rating	70/100	New
Pharmacy pays	~$9.44 /30	—
Type	RX	RX
Active ingredient	LEFLUNOMIDE	PENICILLAMINE
Manufacturer	Sanofi Aventis US	Mylan Speciality LP
Dosage forms	Tablet	Tablet
Drug class	Antirheumatic Agent	Antirheumatic Agent
Boxed warning	Boxed warning	Boxed warning
Treats	Rheumatoid Arthritis	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

arava depen

Rating

70/100

New

Pharmacy pays

~$9.44 /30

—

Type

Active ingredient

LEFLUNOMIDE

PENICILLAMINE

Manufacturer

Sanofi Aventis US

Mylan Speciality LP

Dosage forms

Tablet

Drug class

Antirheumatic Agent

Boxed warning

Treats

Rheumatoid Arthritis

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

Frequently asked questions

What is the difference between Arava and Depen?

Arava contains Leflunomide, while Depen contains Penicillamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.