APTENSIO XR vs COTEMPLA XR-ODT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. APTENSIO XR and COTEMPLA XR-ODT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	APTENSIO XR	COTEMPLA XR-ODT
Rating	New	New
Pharmacy pays	~$18.94 /30	~$18.94 /30
Type	RX	RX
Active ingredient	METHYLPHENIDATE HYDROCHLORIDE	METHYLPHENIDATE
Manufacturer	Rhodes Pharms	Neos Theraps Inc
Dosage forms	Capsule, extended release	Tablet, orally disintegrating
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 2.7 hours	about 2.7 hours
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

aptensio xr cotempla xr-odt

Rating

New

Pharmacy pays

~$18.94 /30

Type

Active ingredient

METHYLPHENIDATE HYDROCHLORIDE

METHYLPHENIDATE

Manufacturer

Rhodes Pharms

Neos Theraps Inc

Dosage forms

Capsule, extended release

Tablet, orally disintegrating

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

about 2.7 hours

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is cheaper, Aptensio XR or Cotempla XR-ODT?

Pharmacies pay about the same to acquire either one — roughly $18.94 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Aptensio XR and Cotempla XR-ODT?

Aptensio XR contains Methylphenidate Hydrochloride, while Cotempla XR-ODT contains Methylphenidate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.