APRISO vs AZULFIDINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. APRISO and AZULFIDINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	APRISO	AZULFIDINE
Rating	New	New
Pharmacy pays	~$26.72 /30	~$5.92 /30
Type	RX	RX
Active ingredient	MESALAMINE	SULFASALAZINE
Manufacturer	Salix	Pharmacia and Upjohn
Dosage forms	Capsule, extended release	Tablet
Drug class	Aminosalicylate	Aminosalicylate
Boxed warning	None	None
Half-life	about 7 to 9 hours (apparent terminal half-life)	—
Treats	Ulcerative Colitis, Proctitis, Sigmoid Diseases	Juvenile Arthritis, Rheumatoid Arthritis, Ulcerative Colitis

apriso azulfidine

Rating

New

Pharmacy pays

~$26.72 /30

~$5.92 /30

Type

Active ingredient

MESALAMINE

SULFASALAZINE

Manufacturer

Salix

Pharmacia and Upjohn

Dosage forms

Capsule, extended release

Tablet

Drug class

Aminosalicylate

Boxed warning

None

Half-life

about 7 to 9 hours (apparent terminal half-life)

—

Treats

Ulcerative Colitis, Proctitis, Sigmoid Diseases

Juvenile Arthritis, Rheumatoid Arthritis, Ulcerative Colitis

Frequently asked questions

Which is cheaper, Apriso or Azulfidine?

Azulfidine costs pharmacies less to acquire — about $5.92 vs $26.72 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Apriso and Azulfidine?

Apriso contains Mesalamine, while Azulfidine contains Sulfasalazine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.