APREMILAST vs ZORYVE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. APREMILAST and ZORYVE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	APREMILAST	ZORYVE
Rating	70/100	New
Pharmacy pays	—	~$10.09 /30
Type	RX	RX
Active ingredient	APREMILAST	ROFLUMILAST
Manufacturer	Macleods Pharms Ltd	Arcutis
Dosage forms	Tablet	Spray/Inhaler, Topical
Drug class	Phosphodiesterase 4 Inhibitor	Phosphodiesterase 4 Inhibitor
Boxed warning	None	None
Half-life	about 6 to 9 hours (terminal elimination half-life)	—
Treats	Psoriatic Arthritis	Chronic Obstructive Pulmonary Disease

apremilast zoryve

Rating

70/100

New

Pharmacy pays

—

~$10.09 /30

Type

Active ingredient

APREMILAST

ROFLUMILAST

Manufacturer

Macleods Pharms Ltd

Arcutis

Dosage forms

Tablet

Spray/Inhaler, Topical

Drug class

Phosphodiesterase 4 Inhibitor

Boxed warning

None

Half-life

about 6 to 9 hours (terminal elimination half-life)

—

Treats

Psoriatic Arthritis

Chronic Obstructive Pulmonary Disease

Frequently asked questions

What is the difference between Apremilast and Zoryve?

Apremilast contains Apremilast, while Zoryve contains Roflumilast — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.