APLENZIN vs ZYBAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. APLENZIN and ZYBAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	APLENZIN	ZYBAN
Rating	New	70/100
Pharmacy pays	~$2.52 /30	~$2.52 /30
Type	RX	RX
Active ingredient	BUPROPION HYDROBROMIDE	BUPROPION HYDROCHLORIDE
Manufacturer	Bausch	Glaxosmithkline
Dosage forms	Tablet, extended release	Tablet, extended release
Drug class	Aminoketone	Aminoketone
Boxed warning	Boxed warning	None
Half-life	about 21 hours on average (±9 hours)	about 21 hours on average (±9 hours)
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder

aplenzin zyban

Rating

New

70/100

Pharmacy pays

~$2.52 /30

Type

Active ingredient

BUPROPION HYDROBROMIDE

BUPROPION HYDROCHLORIDE

Manufacturer

Bausch

Glaxosmithkline

Dosage forms

Tablet, extended release

Drug class

Aminoketone

Boxed warning

None

Half-life

about 21 hours on average (±9 hours)

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder

Get zybanhigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Get treatment online

Licensed online providers — consult & get prescribed if eligible.

SesameCompare online visit prices

Frequently asked questions

Which is cheaper, Aplenzin or Zyban?

Pharmacies pay about the same to acquire either one — roughly $2.52 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Aplenzin and Zyban?

Aplenzin contains Bupropion Hydrobromide, while Zyban contains Bupropion Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.