APLENZIN vs WELLBUTRIN XL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. APLENZIN and WELLBUTRIN XL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	APLENZIN	WELLBUTRIN XL
Rating	New	New
Pharmacy pays	~$2.52 /30	~$2.52 /30
Type	RX	RX
Active ingredient	BUPROPION HYDROBROMIDE	BUPROPION HYDROCHLORIDE
Manufacturer	Bausch	Bausch
Dosage forms	Tablet, extended release	Tablet, extended release
Drug class	Aminoketone	Aminoketone
Boxed warning	Boxed warning	Boxed warning
Half-life	about 21 hours on average (±9 hours)	about 21 hours on average (±9 hours)
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder

aplenzin wellbutrin xl

Rating

New

Pharmacy pays

~$2.52 /30

Type

Active ingredient

BUPROPION HYDROBROMIDE

BUPROPION HYDROCHLORIDE

Manufacturer

Bausch

Dosage forms

Tablet, extended release

Drug class

Aminoketone

Boxed warning

Half-life

about 21 hours on average (±9 hours)

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder

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Frequently asked questions

Which is cheaper, Aplenzin or Wellbutrin XL?

Pharmacies pay about the same to acquire either one — roughly $2.52 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Aplenzin and Wellbutrin XL?

Aplenzin contains Bupropion Hydrobromide, while Wellbutrin XL contains Bupropion Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.