APIXABAN vs XARELTO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. APIXABAN and XARELTO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	APIXABAN	XARELTO
Rating	66/100	70/100
Pharmacy pays	—	$0.98 /mL
Type	RX	RX
Active ingredient	APIXABAN	RIVAROXABAN
Manufacturer	Apotex	Janssen Pharms
Dosage forms	Tablet	Powder, Tablet, Kit
Drug class	Factor Xa Inhibitor	Factor Xa Inhibitor
Boxed warning	None	Boxed warning
Half-life	about 12 hours	about 5 to 9 hours (11 to 13 hours in older adults)
Treats	Pulmonary Embolism, Venous Thrombosis	Pulmonary Embolism, Venous Thrombosis

apixaban xarelto

Rating

66/100

70/100

Pharmacy pays

—

$0.98 /mL

Type

Active ingredient

APIXABAN

RIVAROXABAN

Manufacturer

Apotex

Janssen Pharms

Dosage forms

Tablet

Powder, Tablet, Kit

Drug class

Factor Xa Inhibitor

Boxed warning

None

Boxed warning

Half-life

about 12 hours

about 5 to 9 hours (11 to 13 hours in older adults)

Treats

Pulmonary Embolism, Venous Thrombosis

Frequently asked questions

Which is better-rated, Apixaban or Xarelto?

By our independent rating, Xarelto scores higher — 3.5 vs 3.3 out of 5 for Apixaban. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Apixaban and Xarelto?

Apixaban contains Apixaban, while Xarelto contains Rivaroxaban — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.