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ANAFRANIL vs SERZONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. ANAFRANIL and SERZONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
72/100

Pharmacy pays

~$7.16 /30
~$39.92 /30

Type

RX
RX

Active ingredient

CLOMIPRAMINE HYDROCHLORIDE
NEFAZODONE HYDROCHLORIDE

Dosage forms

Capsule
Tablet

Drug class

Tricyclic Antidepressant

Boxed warning

Treats

Depressive Disorder, Obsessive-Compulsive Disorder, Pain
Depressive Disorder, Post-Traumatic Stress Disorders

Get serzonehigher-rated option

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Frequently asked questions

Which is better-rated, Anafranil or Serzone?

By our independent rating, Serzone scores higher — 3.6 vs 3.5 out of 5 for Anafranil. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Anafranil or Serzone?

Anafranil costs pharmacies less to acquire — about $7.16 vs $39.92 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Anafranil and Serzone?

Anafranil contains Clomipramine Hydrochloride, while Serzone contains Nefazodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.