ANAFRANIL vs PAMELOR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. ANAFRANIL and PAMELOR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ANAFRANIL	PAMELOR
Rating	70/100	70/100
Pharmacy pays	~$7.16 /30	$0.17 /mL
Type	RX	RX
Active ingredient	CLOMIPRAMINE HYDROCHLORIDE	NORTRIPTYLINE HYDROCHLORIDE
Manufacturer	Specgx LLC	Specgx LLC
Dosage forms	Capsule	Capsule
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	Boxed warning	None
Treats	Depressive Disorder, Obsessive-Compulsive Disorder, Pain	Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder

anafranil pamelor

Rating

70/100

Pharmacy pays

~$7.16 /30

$0.17 /mL

Type

Active ingredient

CLOMIPRAMINE HYDROCHLORIDE

NORTRIPTYLINE HYDROCHLORIDE

Manufacturer

Specgx LLC

Dosage forms

Capsule

Drug class

Tricyclic Antidepressant

Boxed warning

None

Treats

Depressive Disorder, Obsessive-Compulsive Disorder, Pain

Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder

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Frequently asked questions

Which is better-rated, Anafranil or Pamelor?

Anafranil and Pamelor are tied at 3.5 out of 5 by our independent rating.

What is the difference between Anafranil and Pamelor?

Anafranil contains Clomipramine Hydrochloride, while Pamelor contains Nortriptyline Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.