AMPHETAMINE SULFATE vs VYVANSE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. AMPHETAMINE SULFATE and VYVANSE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMPHETAMINE SULFATE	VYVANSE
Rating	70/100	New
Pharmacy pays	~$478.55 /30	—
Type	RX	RX
Active ingredient	AMPHETAMINE SULFATE	LISDEXAMFETAMINE DIMESYLATE
Manufacturer	Epic Pharma LLC	Takeda Pharms USA
Dosage forms	Tablet	Capsule, Tablet, chewable
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults	less than 1 hour (parent drug)
Treats	Attention Deficit Disorder with Hyperactivity, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Binge Drinking

amphetamine sulfate vyvanse

Rating

70/100

New

Pharmacy pays

~$478.55 /30

—

Type

Active ingredient

AMPHETAMINE SULFATE

LISDEXAMFETAMINE DIMESYLATE

Manufacturer

Epic Pharma LLC

Takeda Pharms USA

Dosage forms

Tablet

Capsule, Tablet, chewable

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

less than 1 hour (parent drug)

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Binge Drinking

Frequently asked questions

What is the difference between Amphetamine Sulfate and Vyvanse?

Amphetamine Sulfate contains Amphetamine Sulfate, while Vyvanse contains Lisdexamfetamine Dimesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.