AMPHETAMINE SULFATE vs METHYLPHENIDATE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. AMPHETAMINE SULFATE and METHYLPHENIDATE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMPHETAMINE SULFATE	METHYLPHENIDATE HYDROCHLORIDE
Rating	70/100	New
Pharmacy pays	~$478.55 /30	~$18.94 /30
Type	RX	RX
Active ingredient	AMPHETAMINE SULFATE	METHYLPHENIDATE HYDROCHLORIDE
Manufacturer	Epic Pharma LLC	Alkem Labs Ltd
Dosage forms	Tablet	Capsule, extended release, Solution, Tablet, Tablet, chewable, Tablet, extended release
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	None
Half-life	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults	about 2.7 hours
Treats	Attention Deficit Disorder with Hyperactivity, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

amphetamine sulfate methylphenidate hydrochloride

Rating

70/100

New

Pharmacy pays

~$478.55 /30

~$18.94 /30

Type

Active ingredient

AMPHETAMINE SULFATE

METHYLPHENIDATE HYDROCHLORIDE

Manufacturer

Epic Pharma LLC

Alkem Labs Ltd

Dosage forms

Tablet

Capsule, extended release, Solution, Tablet, Tablet, chewable, Tablet, extended release

Drug class

Central Nervous System Stimulant

Boxed warning

None

Half-life

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

about 2.7 hours

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is cheaper, Amphetamine Sulfate or Methylphenidate Hydrochloride?

Methylphenidate Hydrochloride costs pharmacies less to acquire — about $18.94 vs $478.55 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Amphetamine Sulfate and Methylphenidate Hydrochloride?

Amphetamine Sulfate contains Amphetamine Sulfate, while Methylphenidate Hydrochloride contains Methylphenidate Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.