AMPHETAMINE SULFATE vs METHYLIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. AMPHETAMINE SULFATE and METHYLIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMPHETAMINE SULFATE	METHYLIN
Rating	70/100	70/100
Pharmacy pays	~$478.55 /30	~$18.94 /30
Type	RX	RX
Active ingredient	AMPHETAMINE SULFATE	METHYLPHENIDATE HYDROCHLORIDE
Manufacturer	Epic Pharma LLC	Specgx LLC
Dosage forms	Tablet	Solution
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults	about 2.7 hours
Treats	Attention Deficit Disorder with Hyperactivity, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

amphetamine sulfate methylin

Rating

70/100

Pharmacy pays

~$478.55 /30

~$18.94 /30

Type

Active ingredient

AMPHETAMINE SULFATE

METHYLPHENIDATE HYDROCHLORIDE

Manufacturer

Epic Pharma LLC

Specgx LLC

Dosage forms

Tablet

Solution

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

about 2.7 hours

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is better-rated, Amphetamine Sulfate or Methylin?

Amphetamine Sulfate and Methylin are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Amphetamine Sulfate or Methylin?

Methylin costs pharmacies less to acquire — about $18.94 vs $478.55 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Amphetamine Sulfate and Methylin?

Amphetamine Sulfate contains Amphetamine Sulfate, while Methylin contains Methylphenidate Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.