AMPHETAMINE SULFATE vs LISDEXAMFETAMINE DIMESYLATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. AMPHETAMINE SULFATE and LISDEXAMFETAMINE DIMESYLATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMPHETAMINE SULFATE	LISDEXAMFETAMINE DIMESYLATE
Rating	70/100	70/100
Pharmacy pays	~$478.55 /30	—
Type	RX	RX
Active ingredient	AMPHETAMINE SULFATE	LISDEXAMFETAMINE DIMESYLATE
Manufacturer	Epic Pharma LLC	Ascent Pharms Inc
Dosage forms	Tablet	Capsule, Tablet, chewable
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults	less than 1 hour (parent drug)
Treats	Attention Deficit Disorder with Hyperactivity, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Binge Drinking

amphetamine sulfate lisdexamfetamine dimesylate

Rating

70/100

Pharmacy pays

~$478.55 /30

—

Type

Active ingredient

AMPHETAMINE SULFATE

LISDEXAMFETAMINE DIMESYLATE

Manufacturer

Epic Pharma LLC

Ascent Pharms Inc

Dosage forms

Tablet

Capsule, Tablet, chewable

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

less than 1 hour (parent drug)

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Binge Drinking

Frequently asked questions

Which is better-rated, Amphetamine Sulfate or Lisdexamfetamine Dimesylate?

Amphetamine Sulfate and Lisdexamfetamine Dimesylate are tied at 3.5 out of 5 by our independent rating.

What is the difference between Amphetamine Sulfate and Lisdexamfetamine Dimesylate?

Amphetamine Sulfate contains Amphetamine Sulfate, while Lisdexamfetamine Dimesylate contains Lisdexamfetamine Dimesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.