AMPHETAMINE SULFATE vs DEXEDRINE SPANSULE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. AMPHETAMINE SULFATE and DEXEDRINE SPANSULE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMPHETAMINE SULFATE	DEXEDRINE SPANSULE
Rating	70/100	70/100
Pharmacy pays	~$478.55 /30	~$29.94 /30
Type	RX	RX
Active ingredient	AMPHETAMINE SULFATE	DEXTROAMPHETAMINE SULFATE
Manufacturer	Epic Pharma LLC	Impax
Dosage forms	Tablet	Capsule, extended release
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults	—
Treats	Attention Deficit Disorder with Hyperactivity, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Narcolepsy

amphetamine sulfate dexedrine spansule

Rating

70/100

Pharmacy pays

~$478.55 /30

~$29.94 /30

Type

Active ingredient

AMPHETAMINE SULFATE

DEXTROAMPHETAMINE SULFATE

Manufacturer

Epic Pharma LLC

Impax

Dosage forms

Tablet

Capsule, extended release

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

—

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Frequently asked questions

Which is better-rated, Amphetamine Sulfate or Dexedrine Spansule?

Amphetamine Sulfate and Dexedrine Spansule are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Amphetamine Sulfate or Dexedrine Spansule?

Dexedrine Spansule costs pharmacies less to acquire — about $29.94 vs $478.55 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Amphetamine Sulfate and Dexedrine Spansule?

Amphetamine Sulfate contains Amphetamine Sulfate, while Dexedrine Spansule contains Dextroamphetamine Sulfate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.