AMPHETAMINE SULFATE vs CAFFEINE CITRATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. AMPHETAMINE SULFATE and CAFFEINE CITRATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMPHETAMINE SULFATE	CAFFEINE CITRATE
Rating	70/100	68/100
Pharmacy pays	~$478.55 /30	~$2.58 /30
Type	RX	RX
Active ingredient	AMPHETAMINE SULFATE	CAFFEINE CITRATE
Manufacturer	Epic Pharma LLC	Fresenius Kabi USA
Dosage forms	Tablet	Injectable, Solution
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	None
Half-life	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults	—
Treats	Attention Deficit Disorder with Hyperactivity, Narcolepsy	Apnea, Fatigue

amphetamine sulfate caffeine citrate

Rating

70/100

68/100

Pharmacy pays

~$478.55 /30

~$2.58 /30

Type

Active ingredient

AMPHETAMINE SULFATE

CAFFEINE CITRATE

Manufacturer

Epic Pharma LLC

Fresenius Kabi USA

Dosage forms

Tablet

Injectable, Solution

Drug class

Central Nervous System Stimulant

Boxed warning

None

Half-life

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

—

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Apnea, Fatigue

Frequently asked questions

Which is better-rated, Amphetamine Sulfate or Caffeine Citrate?

By our independent rating, Amphetamine Sulfate scores higher — 3.5 vs 3.4 out of 5 for Caffeine Citrate. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Amphetamine Sulfate or Caffeine Citrate?

Caffeine Citrate costs pharmacies less to acquire — about $2.58 vs $478.55 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Amphetamine Sulfate and Caffeine Citrate?

Amphetamine Sulfate contains Amphetamine Sulfate, while Caffeine Citrate contains Caffeine Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.