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AMITRIPTYLINE HYDROCHLORIDE vs TOFRANIL-PM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. AMITRIPTYLINE HYDROCHLORIDE and TOFRANIL-PM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

68/100
70/100

Pharmacy pays

~$2.72 /30
~$100.18 /30

Type

RX
RX

Active ingredient

AMITRIPTYLINE HYDROCHLORIDE
IMIPRAMINE PAMOATE

Manufacturer

Dosage forms

Tablet
Capsule

Drug class

Tricyclic Antidepressant
Tricyclic Antidepressant

Boxed warning

Treats

Depressive Disorder, Pain
Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

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Frequently asked questions

Which is better-rated, Amitriptyline Hydrochloride or Tofranil-Pm?

By our independent rating, Tofranil-Pm scores higher — 3.5 vs 3.4 out of 5 for Amitriptyline Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Amitriptyline Hydrochloride or Tofranil-Pm?

Amitriptyline Hydrochloride costs pharmacies less to acquire — about $2.72 vs $100.18 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Amitriptyline Hydrochloride and Tofranil-Pm?

Amitriptyline Hydrochloride contains Amitriptyline Hydrochloride, while Tofranil-Pm contains Imipramine Pamoate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.