AMITRIPTYLINE HYDROCHLORIDE vs NORTRIPTYLINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. AMITRIPTYLINE HYDROCHLORIDE and NORTRIPTYLINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMITRIPTYLINE HYDROCHLORIDE	NORTRIPTYLINE HYDROCHLORIDE
Rating	68/100	68/100
Pharmacy pays	~$2.72 /30	$0.17 /mL
Type	RX	RX
Active ingredient	AMITRIPTYLINE HYDROCHLORIDE	NORTRIPTYLINE HYDROCHLORIDE
Manufacturer	Sandoz	Aurobindo Pharma Ltd
Dosage forms	Tablet	Capsule, Solution
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	Boxed warning	None
Treats	Depressive Disorder, Pain	Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder

amitriptyline hydrochloride nortriptyline hydrochloride

Rating

68/100

Pharmacy pays

~$2.72 /30

$0.17 /mL

Type

Active ingredient

AMITRIPTYLINE HYDROCHLORIDE

NORTRIPTYLINE HYDROCHLORIDE

Manufacturer

Sandoz

Aurobindo Pharma Ltd

Dosage forms

Tablet

Capsule, Solution

Drug class

Tricyclic Antidepressant

Boxed warning

None

Treats

Depressive Disorder, Pain

Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder

Get amitriptyline hydrochloridehigher-rated option

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Frequently asked questions

Which is better-rated, Amitriptyline Hydrochloride or Nortriptyline Hydrochloride?

Amitriptyline Hydrochloride and Nortriptyline Hydrochloride are tied at 3.4 out of 5 by our independent rating.

What is the difference between Amitriptyline Hydrochloride and Nortriptyline Hydrochloride?

Amitriptyline Hydrochloride contains Amitriptyline Hydrochloride, while Nortriptyline Hydrochloride contains Nortriptyline Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.