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AMITRIPTYLINE HYDROCHLORIDE vs IMIPRAMINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. AMITRIPTYLINE HYDROCHLORIDE and IMIPRAMINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

68/100
70/100

Pharmacy pays

~$2.72 /30
~$2.54 /30

Type

RX
RX

Active ingredient

AMITRIPTYLINE HYDROCHLORIDE
IMIPRAMINE HYDROCHLORIDE

Dosage forms

Tablet
Tablet

Drug class

Tricyclic Antidepressant
Tricyclic Antidepressant

Treats

Depressive Disorder, Pain
Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

Get imipramine hydrochloridehigher-rated option

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Frequently asked questions

Which is better-rated, Amitriptyline Hydrochloride or Imipramine Hydrochloride?

By our independent rating, Imipramine Hydrochloride scores higher — 3.5 vs 3.4 out of 5 for Amitriptyline Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Amitriptyline Hydrochloride or Imipramine Hydrochloride?

Imipramine Hydrochloride costs pharmacies less to acquire — about $2.54 vs $2.72 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Amitriptyline Hydrochloride and Imipramine Hydrochloride?

Amitriptyline Hydrochloride contains Amitriptyline Hydrochloride, while Imipramine Hydrochloride contains Imipramine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.