AMITIZA vs MOTEGRITY

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. AMITIZA and MOTEGRITY are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMITIZA	MOTEGRITY
Rating	New	New
Pharmacy pays	~$20.52 /30	~$21.22 /30
Type	RX	RX
Active ingredient	LUBIPROSTONE	PRUCALOPRIDE SUCCINATE
Manufacturer	Sucampo Pharma LLC	Takeda Pharms USA
Dosage forms	Capsule	Tablet
Drug class	Chloride Channel Activator	Serotonin-4 Receptor Agonist
Boxed warning	None	None
Treats	Constipation, Irritable Bowel Syndrome	Constipation

amitiza motegrity

Rating

New

Pharmacy pays

~$20.52 /30

~$21.22 /30

Type

Active ingredient

LUBIPROSTONE

PRUCALOPRIDE SUCCINATE

Manufacturer

Sucampo Pharma LLC

Takeda Pharms USA

Dosage forms

Capsule

Tablet

Drug class

Chloride Channel Activator

Serotonin-4 Receptor Agonist

Boxed warning

None

Treats

Constipation, Irritable Bowel Syndrome

Constipation

Frequently asked questions

Which is cheaper, Amitiza or Motegrity?

Amitiza costs pharmacies less to acquire — about $20.52 vs $21.22 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Amitiza and Motegrity?

Amitiza contains Lubiprostone, while Motegrity contains Prucalopride Succinate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.