AMITIZA vs LINZESS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. AMITIZA and LINZESS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMITIZA	LINZESS
Rating	New	70/100
Pharmacy pays	~$20.52 /30	—
Type	RX	RX
Active ingredient	LUBIPROSTONE	LINACLOTIDE
Manufacturer	Sucampo Pharma LLC	Abbvie
Dosage forms	Capsule	Capsule
Drug class	Chloride Channel Activator	Guanylate Cyclase-C Agonist
Boxed warning	None	Boxed warning
Treats	Constipation, Irritable Bowel Syndrome	Constipation, Irritable Bowel Syndrome

amitiza linzess

Rating

New

70/100

Pharmacy pays

~$20.52 /30

—

Type

Active ingredient

LUBIPROSTONE

LINACLOTIDE

Manufacturer

Sucampo Pharma LLC

Abbvie

Dosage forms

Capsule

Drug class

Chloride Channel Activator

Guanylate Cyclase-C Agonist

Boxed warning

None

Boxed warning

Treats

Constipation, Irritable Bowel Syndrome

Frequently asked questions

What is the difference between Amitiza and Linzess?

Amitiza contains Lubiprostone, while Linzess contains Linaclotide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.