AMITIZA vs LACTULOSE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. AMITIZA and LACTULOSE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMITIZA	LACTULOSE
Rating	New	68/100
Pharmacy pays	~$20.52 /30	~$0.73 /30
Type	RX	RX
Active ingredient	LUBIPROSTONE	LACTULOSE
Manufacturer	Sucampo Pharma LLC	Fresenius Kabi USA
Dosage forms	Capsule	Solution, Powder
Drug class	Chloride Channel Activator	Osmotic Laxative
Boxed warning	None	None
Treats	Constipation, Irritable Bowel Syndrome	Constipation, Hepatic Encephalopathy

amitiza lactulose

Rating

New

68/100

Pharmacy pays

~$20.52 /30

~$0.73 /30

Type

Active ingredient

LUBIPROSTONE

LACTULOSE

Manufacturer

Sucampo Pharma LLC

Fresenius Kabi USA

Dosage forms

Capsule

Solution, Powder

Drug class

Chloride Channel Activator

Osmotic Laxative

Boxed warning

None

Treats

Constipation, Irritable Bowel Syndrome

Constipation, Hepatic Encephalopathy

Frequently asked questions

Which is cheaper, Amitiza or Lactulose?

Lactulose costs pharmacies less to acquire — about $0.73 vs $20.52 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Amitiza and Lactulose?

Amitiza contains Lubiprostone, while Lactulose contains Lactulose — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.