AMITIZA vs IBSRELA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. AMITIZA and IBSRELA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMITIZA	IBSRELA
Rating	New	New
Pharmacy pays	~$20.52 /30	—
Type	RX	RX
Active ingredient	LUBIPROSTONE	TENAPANOR HYDROCHLORIDE
Manufacturer	Sucampo Pharma LLC	Ardelyx Inc
Dosage forms	Capsule	Tablet
Drug class	Chloride Channel Activator	—
Boxed warning	None	Boxed warning
Treats	Constipation, Irritable Bowel Syndrome	Irritable Bowel Syndrome

amitiza ibsrela

Rating

New

Pharmacy pays

~$20.52 /30

—

Type

Active ingredient

LUBIPROSTONE

TENAPANOR HYDROCHLORIDE

Manufacturer

Sucampo Pharma LLC

Ardelyx Inc

Dosage forms

Capsule

Tablet

Drug class

Chloride Channel Activator

—

Boxed warning

None

Boxed warning

Treats

Constipation, Irritable Bowel Syndrome

Irritable Bowel Syndrome

Frequently asked questions

What is the difference between Amitiza and Ibsrela?

Amitiza contains Lubiprostone, while Ibsrela contains Tenapanor Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.