AMITIZA vs DICYCLOMINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. AMITIZA and DICYCLOMINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMITIZA	DICYCLOMINE HYDROCHLORIDE
Rating	New	70/100
Pharmacy pays	~$20.52 /30	~$2.26 /30
Type	RX	RX
Active ingredient	LUBIPROSTONE	DICYCLOMINE HYDROCHLORIDE
Manufacturer	Sucampo Pharma LLC	Lannett Co Inc
Dosage forms	Capsule	Capsule, Injectable, Solution, Tablet
Drug class	Chloride Channel Activator	Anticholinergic
Boxed warning	None	None
Treats	Constipation, Irritable Bowel Syndrome	Irritable Bowel Syndrome

amitiza dicyclomine hydrochloride

Rating

New

70/100

Pharmacy pays

~$20.52 /30

~$2.26 /30

Type

Active ingredient

LUBIPROSTONE

DICYCLOMINE HYDROCHLORIDE

Manufacturer

Sucampo Pharma LLC

Lannett Co Inc

Dosage forms

Capsule

Capsule, Injectable, Solution, Tablet

Drug class

Chloride Channel Activator

Anticholinergic

Boxed warning

None

Treats

Constipation, Irritable Bowel Syndrome

Irritable Bowel Syndrome

Frequently asked questions

Which is cheaper, Amitiza or Dicyclomine Hydrochloride?

Dicyclomine Hydrochloride costs pharmacies less to acquire — about $2.26 vs $20.52 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Amitiza and Dicyclomine Hydrochloride?

Amitiza contains Lubiprostone, while Dicyclomine Hydrochloride contains Dicyclomine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.